منابع مشابه
Vascular Smooth Muscle Calcium Channels
Voltage-gated Ca 21 channels of the plasma membrane open in response to changes in cell membrane potential, providing an important pathway for regulated entry of extracellular Ca ions. Ca channels comprise a family of structurally related proteins displaying tissueand stage-specific expression. They are classified as either high voltage-activated (HVA) or low voltage-activated (LVA) and can be ...
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Hypertension is a progressive disease involving an increase in arterial constriction. It constitutes a major risk factor leading to stroke, heart disease, and kidney failure. Understanding the molecular pathways involved in arterial tone regulation is crucial to increasing our understanding of blood pressure regulation. Recently, a novel mechanism involving small-localized bursts of calcium ins...
متن کاملCalcium and vascular smooth muscle contraction.
Radioactive calcium flux in rabbit aorta was studied to evaluate factors regulating the movement of calcium into and out of the cell. Calcium content was estimated both from (1) the amount of Ca present in the tissue and the specific activity of Ca in the bathing medium, and (2) determination of chemical calcium by atomic absorption spectrophotometry. Calcium efflux was followed by washing aort...
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Pioglitazone, an insulin-sensitizing, antidiabetic agent, has blood pressure-lowering effects in insulin-resistant hypertensive rats and attenuates growth factor-induced increases of intracellular Ca2+ in rat aortic vascular smooth muscle cells. To determine whether modulation of voltage-dependent Ca2+ channels plays a role in this association, we investigated the effects of pioglitazone on vol...
متن کاملRegulation of cytosolic calcium by angiotensins in vascular smooth muscle.
The carboxy terminal homologue of angiotensin II (Ang II), Ang-(3-8) or hexapeptide, was used as a model peptide to examine the types of receptor mechanisms involved in calcium mobilization in cultured vascular smooth muscle cells. Hexapeptide did not produce tachyphylaxis but did produce a sustained increase in intracellular calcium. Differences in the increase in intracellular calcium [( Ca2+...
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ژورنال
عنوان ژورنال: Microcirculation
سال: 2013
ISSN: 1073-9688
DOI: 10.1111/micc.12046